Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report.
Article
Corral Sánchez, María Dolores, Galán Gómez, Víctor, Sastre Urgelles, Ana et al. (2021). Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report.
. 38(5), 504-509. 10.1080/08880018.2021.1889730
Corral Sánchez, María Dolores, Galán Gómez, Víctor, Sastre Urgelles, Ana et al. (2021). Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report.
. 38(5), 504-509. 10.1080/08880018.2021.1889730
Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors, such as larotrectinib, have shown efficacy and safety in the treatment of IFS. We report a case of an abdominal IFS diagnosed in a newborn associated with an aortic aneurysm that was successfully treated with larotrectinib without relevant adverse effects.