Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells Article

Ren, Zhen, Chen, Si, Qing, Tao et al. (2017). Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells . TOXICOLOGY, 392 11-21. 10.1016/j.tox.2017.10.002

Open Access International Collaboration

cited authors

  • Ren, Zhen; Chen, Si; Qing, Tao; Xuan, Jiekun; Couch, Letha; Yu, Dianke; Ning, Baitang; Shi, Leming; Guo, Lei

sustainable development goals

authors

publication date

  • December 1, 2017

published in

keywords

  • ACID-INDUCED TOXICITY
  • CONTRIBUTE
  • CYTOTOXICITY
  • DEATH
  • ER stress
  • Gene expression
  • Leflunomide
  • Life Sciences & Biomedicine
  • Liver toxicity
  • MAPK pathway
  • METABOLISM
  • METHAPYRILENE-INDUCED HEPATOTOXICITY
  • Pharmacology & Pharmacy
  • RHEUMATOID-ARTHRITIS
  • RNA-seq
  • Science & Technology
  • TARGET
  • Toxicology

Digital Object Identifier (DOI)

publisher

  • ELSEVIER IRELAND LTD

start page

  • 11

end page

  • 21

volume

  • 392